Dermatomyositis (DM)

Dermatomyositis (DM) is a rare autoimmune disease that affects both the skin and muscles. It’s estimated that the prevalence of DM is between 1 to 10 cases per million people worldwide.^[22] DM primarily affects adults, with a peak age of onset between 50 and 60 years old and is more common in women than men.²²

The symptoms of DM can vary from person to person, but typically involve muscle weakness and skin changes. Muscle weakness usually affects the muscles closest to the trunk of the body, such as the neck, shoulders, hips, and back. This can result in difficulty with movements like climbing stairs, getting up from a chair, or lifting objects above the head.²²

Skin changes in DM can include a reddish or purple rash on the eyelids, knuckles, elbows, knees, and/or chest, and sometimes a scaly rash on the scalp or face. Over time, affected skin can become thickened and raised.²²

There is currently no cure for DM, but treatment can help manage symptoms and prevent further muscle and skin damage. Treatment typically involves a combination of medications such as corticosteroids, immunosuppressants, and/or biologic agents.^[23] Physical therapy and exercise may also be recommended to help improve muscle strength and function.²³

At Galapagos, we are dedicated to advancing the understanding and treatment of Dermatomyositis, a rare and debilitating autoimmune disease that affects the muscles and skin.