Double Materiality Assessment
To determine our key goals and priorities, we conducted an impact materiality assessment in 2022, which enabled us to identify the topics most relevant to our internal and external stakeholders. The analysis provided insights into our potential impact on society and the world, allowing us to better monitor emerging business challenges and opportunities.
In 2023, to meet the requirement introduced by the European Corporate Sustainability Reporting Directive (CSRD), we completed a first iteration of the double materiality assessment by including, in addition to the impact materiality assessment, a financial materiality assessment. In 2024, we updated our double materiality assessment to reflect the business changes related to the transfer of the Jyseleca® business to Alfasigma as described below.
Engaging with Our Stakeholders
To inform our double materiality process, we engaged with a diverse group of stakeholders, including patient organizations, patient experts, healthcare professionals, research and development partners, supply chain partners, investors, employees, and members of the Management Committee and our Sustainability Steering Committee.
Our engagement process involved structured interviews, surveys, and questionnaires designed to gather feedback from relevant stakeholder groups and to capture a wide range of perspectives regarding impacts, and risks and opportunities associated with our business. Internal and external stakeholders were invited to review a list of potential material topics via a survey to identify the five topics they considered most and least relevant to us and our core mission. They were also given the opportunity to suggest any additional material topics not included in the initial list.
In addition to the surveys and interviews conducted, we maintain an ongoing dialogue with our stakeholders through our sustainability and function leads. Our Board of Directors, Executive Committee, and Management Committee receive regular comprehensive updates on stakeholder expectations around sustainability topics, including ethical business conduct, social and environmental responsibility, ensuring that stakeholder concerns are considered in decision-making at all levels and reinforcing our commitment to sustainability.
The feedback we receive from our stakeholders through both the double materiality assessment and on an ongoing basis, serves as critical input to our sustainability strategy and all elements of our governance and sustainability program as part of our ongoing due diligence, enabling us to better align with our priority areas, such as patient engagement and employee-related topics.
Assessing Our Results
Our stakeholder engagement process provided the basis for the impact materiality portion of our double materiality assessment. A team of internal experts collected and assessed the inputs and topics identified by stakeholders, scoring these based on severity (scale, scope, and likelihood of occurrence) for both positive and negative impacts, as well as the irremediable nature for negative impacts.
For the financial materiality aspect of the double materiality assessment, we assessed the financial risks and opportunities, including (potential) financial effects incorporated in our financial statements. We considered severity aligned with our financial materiality thresholds, as well as likelihood aligned with our internal risk register. This process was followed for all sustainability topics, including climate-related ones. As mentioned in E1-Climate change, we didn’t perform a detailed climate risk analysis.
In 2024, we updated our double materiality assessment to reflect the business changes related to the transfer of the Jyseleca® business to Alfasigma, which impacted the materiality thresholds with regard to our number of employees and financials. The graphic below presents an overview of all the topics that have been determined to be material for us:

Sustainability due diligence
For the Sustainability due diligence, we refer to the related section of our Annual Report.