2010
Expression,
purification and functional characterization of Wnt signaling
co-receptors LRP5 and LRP6
Fleury
D, Vayssiere B, Touitou R, Gillard C, Lebhar H, Rawadi G,
Mollat P
Protein
Expr Purif. 2010 Mar;70(1):39-47. Epub 2009 Aug 27
2009
Functional
studies of membrane-bound and purified human Hedgehog receptor
Patched expressed in yeast
Joubert O, Nehmé R, Fleury D, De Rivoyre M, Bidet
M, Polidori A, Ruat M, Pucci B, Mollat P, Mus-Veteau I.
Biochim Biophys Acta 1788 (2009) 1813–1821
The
alpha7 nicotinic acetylcholine receptor on fibroblast-like
synoviocytes and in synovial tissue from rheumatoid arthritis
patients: a possible role for a key neurotransmitter in
synovial inflammation
van Maanen MA, Stoof SP, van der Zanden EP, de Jonge WJ,
Janssen RA, Fischer DF, Vandeghinste N, Brys R, Vervoordeldonk
MJ, Tak PP
Arthritis Rheum. 2009 May;60(5):1272-81
Adenomatous
polyposis coli-mediated control of beta-catenin is essential
for both chondrogenic and osteogenic differentiation of
skeletal precursors
Miclea RL, Karperien M, Bosch CA, van der Horst G, van der
Valk MA, Kobayashi T, Kronenberg HM, Rawadi G, Akçakaya
P, Löwik CW, Fodde R, Wit JM, Robanus-Maandag EC
BMC Dev Biol. 2009 Apr 8;9:26
Androgen
replacement therapy improves function in male rat muscles
independently of hypertrophy and activation of the Akt/mTOR
pathway
Hourdé C, Jagerschmidt C, Clément-Lacroix
P, Vignaud A, Ammann P, Butler-Browne GS, Ferry A.
Acta Physiol (Oxf). 2009 Apr;195(4):471-82
No
evidence for a bone phenotype in GPRC6A knockout mice under
normal physiological conditions
Wellendorph P, Johansen LD, Jensen AA, Casanova E, Gassmann
M, Deprez P, Clément-Lacroix P, Bettler B, Bräuner-Osborne
H.
J Mol Endocrinol. 2009 Mar;42(3):215-23
The
orphan G protein coupled receptor 3 modulates amyloid-beta
peptide generation in neurons
Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré
K, Vanbrabant M, Coun F, Baekelandt V, Delecourte A, Fischer
DF, Pollet D, De Strooper B, and Merchiers P
Science 2009,323(5916):946-951
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abstract
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2008
Crystallization
and preliminary X-ray analysis of the human androgen receptor
ligand-binding domain with a coactivator-like peptide and
selective androgen receptor modulators.
Thauvin M, Robin-Jagerschmidt C, Nique F, Mollat P, Fleury
D, Prangé T
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Dec
1;64(Pt 12):1159-62
Targeted
disruption of the Wnt regulator Kremen induces limb defects
and high bone density
Ellwanger K, Saito H, Clément-Lacroix P, Maltry N,
Niedermeyer J, Lee WK, Baron R, Rawadi G, Westphal H, Niehrs
C
Mol Cell Biol. 2008 Aug;28(15):4875-82
Wnt
signaling and potential applications in bone diseases
Rawadi G.
Curr Drug Targets. 2008 Jul;9(7):581-90
Expression,
purification and characterization of murine Dkk1 protein
Fleury D, Gillard C, Lebhar H, Vayssière B, Touitou
R, Rawadi G, Mollat P
Protein Expr Purif. 2008 Jul;60(1):74-81
Sustainable
drug discovery: Galapagos' alliance strategy
Hoekema, A
Pharma Focus Asia 2008,8:14-17
2007
A
convenient clinically relevant model of human breast cancer
bone metastasis
Garcia T, Jackson A, Bachelier R, Clément-Lacroix
P, Baron R, Clézardin P, Pujuguet P
Clin Exp Metastasis. 2008;25(1):33-42
Galapagos
and GSK: an innovative alliance in osteoarthritis
Hoekema, A
Global Outsourcing Review 2007,9(1):26-28
Tumor
alphavbeta3 integrin is a therapeutic target for breast
cancer bone metastases
Zhao Y, Bachelier R, Treilleux I, Pujuguet P, Peyruchaud
O, Baron R, Clément-Lacroix P, Clézardin P
Cancer Res. 2007 Jun 15;67(12):5821-30
Targeting
the Wnt/beta-catenin pathway to regulate bone formation
in the adult skeleton
Baron R, Rawadi G
Endocrinology. 2007 Jun;148(6):2635-43
Wnt
signaling and the regulation of bone mass.
Baron R, Rawadi G
Curr Osteoporos Rep. 2007 Jun;5(2):73-80
Thyroid
hormone excess rather than thyrotropin deficiency induces
osteoporosis in hyperthyroidism
Bassett JH, O'Shea PJ, Sriskantharajah S, Rabier B, Boyde
A, Howell PG, Weiss RE, Roux JP, Malaval L, Clement-Lacroix
P, Samarut J, Chassande O, Williams GR
Mol Endocrinol. 2007 May;21(5):1095-107
Anti-rheumatic
activities of histone deacetylase (HDAC) inhibitors in vivo
in collagen-induced arthritis in rodents
Lin HS, Hu CY, Chan HY, Liew YY, Huang HP, Lepescheux L,
Bastianelli E, Baron R, Rawadi G, Clément-Lacroix
P
Br J Pharmacol. 2007 Apr;150(7):862-72
Sharing
risks and rewards: basis for a turnkey pharma-biotech alliance
in osteoarthritis
Hoekema, A
Drug Discov World. 2007 Spring:53-58
Expression,
purification, characterization and crystallization of a
recombinant human cytosolic beta-glucosidase produced in
insect cells
Fleury D, Domaingue P, Gillard C, Touitou R, Mollat P
Protein Expr Purif. 2007 Mar;52(1):96-103
Selected 2002-2006
Biology
calls the targets: combining RNAi and disease biology
van Es HH, Arts GJ
Drug Discov Today. 2005 Oct 15;10(20):1385-91
Functional
screening of viral siRNA libraries in human primary cells
Bortone K, Michiels F, Vandeghinste N, Tomme P, and van
Es H.
Drug Discov World. 2004 Fall:20-27
Adenoviral
vectors expressing siRNAs for discovery and validation of
gene function
Arts GJ, Langemeijer E, Tissingh R, Ma L, Pavliska H, Dokic
K, Dooijes R, Mesic E, Clasen R, Michiels F, van der Schueren
J, Lambrecht M, Herman S, Brys R, Thys K, Hoffmann M, Tomme
P, van Es H
Genome Res. 2003 Oct;13(10):2325-32
Arrayed
adenoviral expression libraries for functional screening
Michiels F, van Es H, van Rompaey L, Merchiers P, Francken
B, Pittois K, van der Schueren J, Brys R, Vandersmissen
J, Beirinckx F, Herman S, Dokic K, Klaassen H, Narinx E,
Hagers A, Laenen W, Piest I, Pavliska H, Rombout Y, Langemeijer
E, Ma L, Schipper C, Raeymaeker MD, Schweicher S, Jans M,
van Beeck K, Tsang IR, van de Stolpe O, Tomme P, Arts GJ,
Donker J
Nat Biotechnol. 2002 Nov;20(11):1154-7. Erratum in: Nat
Biotechnol. 2003 Feb;21(2):199
