GLPG0187 Cancer
Galapagos’ candidate drug, GLPG0187, is an integrin receptor antagonist (IRA) that binds to six integrin receptors known to be present in many metastatic cancers, affording a unique anti-integrin profile. In animal studies, oral administration of GLPG0187 as a single agent has been shown to inhibit multiple processes involved in the spread and growth of metastatic tumors. GLPG0187 therefore offers a new approach to treat metastases, a severe complication of many cancers. In the first-in-human trial, GLPG0187 showed good safety and a promising biomarker profile in healthy volunteers. Based on these results, Galapagos initiated a Phase Ib study in March 2011. In this Phase Ib study, Galapagos plans to assess the safety and explore the preliminary efficacy of GLPG0187 in cancer patients.
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Related posters, presentations and publications
Molecular imaging demonstrates GLPG0187, a small-molecule integrin antagonist, binds to RGD-integrin receptors in vivo and is efficacious in tumor and metastasis models
Pujuguet P, Berrocal E, Heckmann B, Wigerinck P, Lorenzon G, Clément-Lacroix P, Bormans G, Deroose
EORTC-NCI-ASCO Annual Meeting on Molecular Markers in Cancer
October 2011
GLPG0187, a small molecule integrin antagonist, shows good safety and decrease in CTx levels in a single ascending dose study
Vanhoutte F, Lorenzon G, Gheyle L, Vets E, Namour F, Pujuguet P, Clément-Lacroix P, Blockhuys C, Wigerinck P
Knowledge for Growth
May 2010
GLPG0187 inhibits progression of established bone metastasis and achieves maximum efficacy when combined with standard-of-care metastatic breast cancer treatments
Clément-Lacroix P, Berrocal E, Heckmann B, Wigerinck P, Lorenzon G, Pujuguet P
International Conference on Cancer-Induced Bone Disease
September 2010
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