June 2006, Galapagos signed a broad alliance with GSK to discover and develop breakthrough medicines in osteoarthritis. This multi-target, multi-year alliance runs from target discovery through to delivery of a clinical proof of concept. In June 2007, the scope of the alliance was expanded to include up to two drug discovery programs on selected GSK drug targets. In December 2008, Galapagos announced that the alliance was further expanded to include two additional drug targets. In December 2009, the alliance was again expanded to include additional drug discovery programs based on novel drug target GT622. Based on these expansions, the alliance is now worth more than €200 million in milestones, plus up to double-digit royalties.